PUBLICATIONS

† denotes equal contribution
* denotes corresponding authors

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Preprints/Submitted Manuscripts

  1. Ctortecka, C.; Jaishankar, D.; Su, P.; Huang, C.-F.; Pla, I.; Henning, N.; Hollas, M. A. R.; Callegari, M. A.; Taylor, M. E.; Lee, Y. M.; Daud, A.; Pinelli, D. F.; Rohan, V.; Caldwell, M. A.; Forte, E.; Sanchez, A.; Kelleher, N. L.; Nadig, S. N.; Top-Down Proteomics in the Assessment of Kidney Donor Quality: a novel approach to increased organ utilization. medRxiv, 2026.02.02.26345404. DOI: 10.64898/2026.02.02.26345404. (Submitted to Am. J. Transplant.)
  2. Lee, A. S.; Huang, C.-F.; Su, T.; Bodner, J.; Kelleher, N. L.; Foltz, D. R.; Replication stress alters CENP-A nucleosome stability during S phase. bioRxiv, 2025.05.23.655122. DOI: 10.1101/2025.05.23.655122. (Submitted to PLOS Biol.)
  3. Gu, Z.; Kimmel, B. R.; Modica, J. A.; Huang, C.-F.; Salaria, R. K.; Sridhar, S.; Kelleher, N. L.; Mrksich M.; Affinity Enhancement in Discrete Multivalent MegaMolecules. (Submitted to ChemBioChem.)

Peer-Reviewed Publications

Huang Group @ TAMU Chemistry

Coming soon!

Prior to Texas A&M

  1. Sanchez, A.; Pla, I.;Huang, C.-F.; Kanchustambham, V. L.; Hollas, M. A. R.; Ladner, D. P.; Peterson, K. N.; Fisher T. D.; Su, T; Mattamana, B. B.; Melani, R. D.; Caldwell, M. A.; McGee, J.;Forte, E.; Kelleher, N. L.; Mapping the Soluble Proteoforms Landscapes from Acetonitrile Precipitated Plasma Samples. J. Am. Soc. Mass Spectrom. 2026, 37(1), 188-199. DOI: 10.1021/jasms.5c00289.
  2. Huang, C.-F.; Su, T.; Flozak, A. S.; Gottardi, C. J.; Kelleher, N. L.; Intact Mass Profiling Reveals Phospho-Proteoforms of the Catenins (85-110 kDa) Regulated by Actomyosin Contractility. Angew. Chem. Int. Ed. 2025, 64(52), e18593. DOI: 10.1002/anie.202518593.
  3. Xu, T.; Su, T.; Des Soye, B.; Kandi, S.; Huang, C.-F.; Wilkins, J.; Kafader, J.; Patrie, S.; Vassar, R.; Kelleher, N.; The Proteoform Landscape of Tau from the Human Brain. J. Proteome Res. 2025, 24(6), 2916–2925. DOI: 10.1021/acs.jproteome.5c00139.
  4. Le, P. M.; Quinn, J. M.; Steffeck, A. W. T.; Flozak, A. S.; Huang, C.-F.; Gottardi, C. J.; α-Catenin Phosphorylation Is Elevated During Mitosis to Resist Apical Rounding and Epithelial Barrier Leak. Biol. Open 2025, 14(1), bio061726. DOI: 10.1242/bio.061726.
  5. Zou, Y.†; Huang, C.-F.†; Sturrock, G. R.; Kelleher, N. L.; Fitzgerald, M. C.; Top-Down Stability of Proteins from Rates of Oxidation (TD-SPROX) Approach for Measuring Proteoform Specific Folding Stability. Anal. Chem. 2024, 96(49), 19597–19604. DOI: 10.1021/acs.analchem.4c04469. (†Co-first authors)
  6. Forte, E.; Sanders, J. M.; Pla, I.; Kanchustambham, V. L.; Hollas, M. A. R.; Huang, C.-F.; Sanchez, A.; Peterson, K. N.; Melani, R. D.; Huang, A.; Polineni, P.; Doll, J. M.; Dietch, Z.; Kelleher, N. L.; Ladner, D. P.; Top-Down Proteomics Identifies Plasma Proteoform Signatures of Liver Cirrhosis Progression. Mol. Cell. Proteom. 2024, 23(12), 100876. DOI: 10.1016/j.mcpro.2024.100876.
  7. Huang, C.-F.; Hollas, M. A. R.; Sanchez, A.; Bhattacharya, M.; Ho, G.; Sundaresan, A.; Caldwell, M. A.; Zhao, X.; Benz, R.; Siddiqui, A.; Kelleher, N. L.; Deep Profiling of Plasma Proteoforms with Engineered Nanoparticles for Top-Down Proteomics. J. Proteome Res. 2024, 23(10), 4694–4703. DOI: 10.1021/acs.jproteome.4c00621.
  8. Huang, C.-F.; Kline, J.; Negrão, F.; Robey, M.; Toby, T.; Durbin, K.; Fellers, R.; Friedewald, J.; Levitsky, J.; Abecassis, M.; Melani, R.; Kelleher, N.; Fornelli, L.; Targeted Quantification of Proteoforms in Complex Samples by Proteoform Reaction Monitoring. Anal. Chem. 2024, 96(8), 3578-3586. DOI: 10.1021/acs.analchem.3c05578.
  9. Huang, C.-F.†; Su, P.†; Fisher, T. D.; Levitsky, J.; Kelleher, N. L.; Forte, E; Mass Spectrometry-Based Approaches for Advancing Transplantation Research. Front. Transplant. 2023, 2. DOI: 10.3389/frtra.2023.1286881.
  10. Huang, C.-F.; Gottardi, C. J.; Mrksich, M; Tyrosine Phosphatase Activity Is Restricted by Basic Charge Substituting Mutation of Substrates. Sci. Rep. 2022, 12, 15095. DOI: 10.1038/s41598-022-19133-4.
  11. Huang, C.-F.; Mrksich, M; Profiling Protein Tyrosine Phosphatase Specificity with Self-Assembled Monolayers for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry and Peptide Arrays. ACS Comb. Sci. 2019, 21, 760-769. DOI: 10.1021/acscombsci.9b00152.
  12. Szymczak, L. C.; Huang, C.-F.; Berns, E. J.; Mrksich, M.; Combining SAMDI Mass Spectrometry and Peptide Arrays to Profile Phosphatase Activities. Methods Enzymol. 2018, 607, 389-403. DOI: 10.1016/bs.mie.2018.04.021.
  13. Wood, S. E.; Sinsinbar, G.; Gudlur, S.; Nallani, M.; Huang, C.-F.; Liedberg, B.; Mrksich, M., A Bottom-Up Proteomic Approach to Identify Substrate Specificity of Outer-Membrane Protease OmpT. Angew. Chem. Int. Ed. 2017, 56(52), 16531-16535. DOI: 10.1002/anie.201707535.
  14. Huang, C.-F.; Liu, Y.-H.; Tai, H.-C., Synthesis of Peptides Containing 2-Oxohistidine Residues and Their Characterization by Liquid Chromatography-Tandem Mass Spectrometry. J. Pept. Sci. 2015, 21(2), 114-119. DOI: 10.1002/psc.2735.